ASTM E1687-2010 测定金属加工液中的直馏基础油的致癌性的标准试验方法
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【英文标准名称】:StandardTestMethodforDeterminingCarcinogenicPotentialofVirginBaseOilsinMetalworkingFluids
【原文标准名称】:测定金属加工液中的直馏基础油的致癌性的标准试验方法
【标准号】:ASTME1687-2010
【标准状态】:现行
【国别】:美国
【发布日期】:2010
【实施或试行日期】:
【发布单位】:美国材料与试验协会(US-ASTM)
【起草单位】:E34.50
【标准类型】:(TestMethod)
【标准水平】:()
【中文主题词】:
【英文主题词】:baseoils;dermalcarcinogenicity;modifiedAmestest;mutagenicity;Baseoils;Carcinogenicity;Dermalexposure;Metalworkingfluids/relatedmedia;ModifiedAmestest;Mutagenicity;Virginbaseoils
【摘要】:ThetestmethodisbasedonamodificationoftheAmesSalmonellamutagenesisassay.Asmodified,thereisgoodcorrelationwithmouseskin-paintingbioassayresultsforsamplesofrawandrefinedlubricatingoilprocessstreams.Mutagenicpotencyinthismodifiedassayandcarcinogenicityintheskin-paintingbioassayalsocorrelatewiththecontentof3to7ringPACs,whichincludepolycyclicaromatichydrocarbonsandtheirheterocyclicanalogs.ThestrengthofthesecorrelationsimpliesthatPACsaretheprincipalmutagenicandcarcinogenicspeciesintheseoils.SomeofthemethodsthathaveprovidedevidencesupportingthisviewarereferencedinAppendixX1.1.1ThistestmethodcoversamicrobiologicaltestprocedurebasedupontheSalmonellamutagenesisassayofAmesetal(1)(seealsoMaronetal(2)).Itcanbeusedasascreeningtechniquetodetectthepresenceofpotentialdermalcarcinogensinvirginbaseoilsusedintheformulationofmetalworkingoils.Personswhoperformthistestshouldbewell-versedintheconductoftheAmestestandconversantwiththephysicalandchemicalpropertiesofpetroleumproducts.1.2Thetestmethodisnotrecommendedasthesoletestingprocedureforoilswhichhaveviscositieslessthan18cSt(90SUS)at40x00B0;C,orforformulatedmetalworkingfluids.1.3ThevaluesstatedinSIunitsaretoberegardedasthestandard.Thevaluesgiveninparenthesesareprovidedforinformationonly.1.4Thisstandarddoesnotpurporttoaddressallofthesafetyconcerns,ifany,associatedwithitsuse.Itistheresponsibilityoftheuserofthisstandardtoestablishappropriatesafetyandhealthpracticesanddeterminetheapplicabilityofregulatorylimitationspriortouse.Section7providesgeneralguidelinesforsafeconductofthistestmethod.
【中国标准分类号】:E39
【国际标准分类号】:
【页数】:8P.;A4
【正文语种】:英语
【原文标准名称】:测定金属加工液中的直馏基础油的致癌性的标准试验方法
【标准号】:ASTME1687-2010
【标准状态】:现行
【国别】:美国
【发布日期】:2010
【实施或试行日期】:
【发布单位】:美国材料与试验协会(US-ASTM)
【起草单位】:E34.50
【标准类型】:(TestMethod)
【标准水平】:()
【中文主题词】:
【英文主题词】:baseoils;dermalcarcinogenicity;modifiedAmestest;mutagenicity;Baseoils;Carcinogenicity;Dermalexposure;Metalworkingfluids/relatedmedia;ModifiedAmestest;Mutagenicity;Virginbaseoils
【摘要】:ThetestmethodisbasedonamodificationoftheAmesSalmonellamutagenesisassay.Asmodified,thereisgoodcorrelationwithmouseskin-paintingbioassayresultsforsamplesofrawandrefinedlubricatingoilprocessstreams.Mutagenicpotencyinthismodifiedassayandcarcinogenicityintheskin-paintingbioassayalsocorrelatewiththecontentof3to7ringPACs,whichincludepolycyclicaromatichydrocarbonsandtheirheterocyclicanalogs.ThestrengthofthesecorrelationsimpliesthatPACsaretheprincipalmutagenicandcarcinogenicspeciesintheseoils.SomeofthemethodsthathaveprovidedevidencesupportingthisviewarereferencedinAppendixX1.1.1ThistestmethodcoversamicrobiologicaltestprocedurebasedupontheSalmonellamutagenesisassayofAmesetal(1)(seealsoMaronetal(2)).Itcanbeusedasascreeningtechniquetodetectthepresenceofpotentialdermalcarcinogensinvirginbaseoilsusedintheformulationofmetalworkingoils.Personswhoperformthistestshouldbewell-versedintheconductoftheAmestestandconversantwiththephysicalandchemicalpropertiesofpetroleumproducts.1.2Thetestmethodisnotrecommendedasthesoletestingprocedureforoilswhichhaveviscositieslessthan18cSt(90SUS)at40x00B0;C,orforformulatedmetalworkingfluids.1.3ThevaluesstatedinSIunitsaretoberegardedasthestandard.Thevaluesgiveninparenthesesareprovidedforinformationonly.1.4Thisstandarddoesnotpurporttoaddressallofthesafetyconcerns,ifany,associatedwithitsuse.Itistheresponsibilityoftheuserofthisstandardtoestablishappropriatesafetyandhealthpracticesanddeterminetheapplicabilityofregulatorylimitationspriortouse.Section7providesgeneralguidelinesforsafeconductofthistestmethod.
【中国标准分类号】:E39
【国际标准分类号】:
【页数】:8P.;A4
【正文语种】:英语
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